Cowley Lab
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  • Home
  • People
  • Research
  • Publications
  • Funding
  • More...
    • Awards
    • Conferences and activities
    • Useful resources
    • Photo gallery
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YOUR CART

Publications

LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response
Simmers MD, Jima DD, Tsuji Y & Cowley M
Submitted

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The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced non-alcoholic fatty liver disease
Riegl SD, Starnes C, Jima DD, Baptissart M, Diehl AM, Belcher SM & Cowley M
Toxicol Sci, 2022, in press

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Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction
Simmers MD, Hudson KM, Baptissart M & Cowley M
Epigenetics, 2022, in press

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Genomic map of candidate human imprint control regions: the imprintome
Jima DD, Skaar DA, Planchart A, Motsinger-Reif A, Cevik SE, Park SS, Cowley M, Wright F, House J, Liu A, Jirtle RL & Hoyo C
Epigenetics, 2022, in press


Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome
Baptissart M, Bradish CM, Jones BS, Walsh E, Tehrani J, Marrero-Colon V, Mehta S, Jima DD, Oh SH, Diehl AM, Fougeray T, Guillou H & Cowley M
Hepatology, 2022, 76(4):1090
  • Read the press release!
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Transcriptomic, proteomic, and metabolomic analyses identify candidate pathways linking maternal cadmium exposure to altered neurodevelopment and behavior
Hudson KM, Shiver E, Yu J, Mehta S, Jima DD, Kane MA, Patisaul HB & Cowley M
Sci Rep, 2021, 11:16302
  • Awarded second place in the Paper of the Year Award by the Society of Toxicology Molecular and Systems Biology Specialty Section. Read the CHHE news article!
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Imprinted gene expression and function of the Dopa decarboxylase gene in the developing heart
Prickett AR, Montibus B, Barkas N, Amante SM, Franco MM, Cowley M, Puszyk W, Shannon MF, Irving M, Madon-Simon M, Ward A, Schulz R, Baldwin HS & Oakey RJ
Front Cell Dev Biol, 2021, 9:676543


Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing
Amante SM, Montibus B, Cowley M, Barkas N, Setiadi J, Saadeh H, Giemza J, Contreras Castillo S, Fleischanderl K, Schulz R & Oakey RJ
Nucleic Acids Res, 2020, 48(15):8349

Maternal cadmium exposure in the mouse leads to increased heart weight at birth and programs susceptibility to hypertension in adulthood
Hudson KM, Belcher SM & Cowley M
Sci Rep, 2019, 9:13553

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Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study
Martin CL, Jima DD, Sharp GC, McCullough LE, Park SS, Gowdy KM, Skaar DA, Cowley M, Maguire RL, Fuemmeler B, Collier D, Relton CL, Murphy SK & Hoyo C (2019)
Epigenetics, 2019, 14(4):325


Neonatal mice exposed to a high fat diet ​in utero influence the behaviour of their nursing dam
Baptissart M, Lamb HE, To K, Bradish C, Tehrani J, Reif D & Cowley M
Proc R Soc B, 2018, 285:20181237

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Comment in: John RM (2019) Prenatal adversity modulates the quality of maternal care via the exposed offspring. Bioessays, 41(6):e1900025.

Effects of cadmium exposure on DNA methylation at imprinting control regions and genome-wide in mothers and newborn children
Cowley M*, Skaar DA, Jima DD, Maguire R, Hudson KM, Park SS, Sorrow P & Hoyo C
Environ Health Perspect, 2018, 126(3):037003
​*corresponding author

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Developmental origins of health and disease
Cowley M
In Smart RC, Hodgson E (Eds.), Molecular and Biochemical Toxicology Fifth Edition (pp.933-943), 2018, Hoboken, NJ: Wiley & Sons, Inc.
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Regulatory links between imprinted genes: evolutionary predictions and consequences ​
Patten MM, Cowley M, Oakey RJ & Feil R
Proc R Soc B, 2016, 283(1824)
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Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes
Madon-Simon M, Cowley M, Garfield AS, Moorwood K, Bauer SR & Ward A
BMC Biol, 2014, 12(1):771

Comment in: Haig D (2014) Frugal fat or munificent muscle: genomic imprinting and metabolism. BMC Biol, 12(1):772.​

Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup
Cowley M, Garfield AS, Madon-Simon M, Charalambous M, Clarkson RW, Smalley MJ, Kendrick H, Isles AR, Parry AJ, Carney S, Oakey RJ, Heisler K, Moorwood K, Wolf JB & Ward A
PLoS Biol, 2014, 12(2):e1001799

Comment in: Wilkins JF (2014) Genomic imprinting of Grb10: Coadaptation or conflict? PLoS Biol, 12(2):e1001800.
Comment in: Ubeda F & Gardner A (2015) Mother and offspring in conflict: why not? PLoS Biol, 13(3):e1002084.
Response to Ubeda & Gardner: Wolf JB, Cowley M & Ward A (2015) Coadaptation between mother and offspring: why not? PLoS Biol, 13(3):e1002085.​

Transposable elements re-wire and fine-tune the transcriptome
Cowley M & Oakey RJ
PLoS Genet, 2013, 9(1): e1003234


Resetting for the next generation
Cowley M & Oakey RJ
Mol Cell, 2012, 48(6):819-21


Epigenetic control of alternative mRNA processing at the imprinted Herc3/Nap1l5 locus
Cowley M, Wood AJ, Böhm S, Schulz R & Oakey RJ
Nucleic Acids Res, 2012, 40(18):8917-26


Protection against de novo methylation is instrumental in maintaining parent-of-origin methylation inherited from the gametes
Proudhon C, Duffié R, Ajjan S, Cowley M, Carbajosa G, Iranzo J, Holland M, Oakey RJ, Rakyan V, Schulz R & Bourc’his D
Mol Cell, 2012, 47(6):909-20


Distinct physiological and behavioural functions for parental alleles of imprinted Grb10
Garfield AS, Cowley M, Smith FM, Moorwood K, Stewart-Cox JE, Gilroy K, Baker S, Xia J, Dalley JW, Hurst LD, Wilkinson LS, Isles AR & Ward A
Nature, 2011, 469:534-8

Comment in: Haig D & Ubeda F (2011) Genomic imprinting: an obsession with depilatory mice. Curr Biol, 21:R257-9.
Comment in: Curley JP (2011) Is there a genomically imprinted social brain? Bioessays, 33:662-8.

Short interspersed element (SINE) depletion and long interspersed element (LINE) abundance are not features universally required for imprinting
Cowley M, de Burca A, McCole RB, Chahal M, Saadat G, Oakey RJ & Schulz R
PLoS ONE, 2011, 6(4): e18953


Human imprinted retrogenes have small DMRs that exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes
Monk D, Arnaud P, Frost JM, Wood AJ, Cowley M, Trullijo AM, Adkins AG, Platas II, Camprubi C, Bourc’his D, Feil R, Moore GE & Oakey RJ
Nucleic Acids Res, 2011, 39(11):4577-86


Retrotransposition and genomic imprinting
Cowley M & Oakey RJ
Brief Funct Genomics, 2010, 9(4):340-6


Maternally-inherited Grb10 reduces placental size and efficiency
Charalambous M, Cowley M, Geoghegan F, Smith FM, Radford EJ, Marlow BP, Graham CF, Hurst LD & Ward A
Dev Biol, 2010, 337(1):1-8


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