Publications

Manuscripts submitted or in revision

Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome
Baptissart M, Bradish CM, Jones B, Walsh E, Tehrani J, Mehta S, Jima DD, Fougeray T, Guillou H & Cowley M (in revision)

Transcriptomic, proteomic, and metabolomic analyses identify candidate pathways linking maternal cadmium exposure to altered neurodevelopment and behavior
Hudson KM, Shiver E, Yu J, Mehta S, Jima DD, Kane MA, Patisaul HB & Cowley M (in revision)

Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction
Simmers MD, Hudson KM, Baptissart M & Cowley M (submitted)

Published manuscripts

Imprinted gene expression and function of the Dopa decarboxylase gene in the developing heart
Prickett AR, Montibus B, Barkas N, Amante SM, Franco MM, Cowley M, Puszyk W, Shannon MF, Irving M, Madon-Simon M, Ward A, Schulz R, Baldwin HS & Oakey RJ (2021) Front Cell Dev Biol, 9:676543.

Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing.
Amante SM, Montibus B, Cowley M, Barkas N, Setiadi J, Saadeh H, Giemza J, Contreras Castillo S, Fleischanderl K, Schulz R & Oakey RJ (2020) Nucleic Acids Res, 48(15):8349.

Maternal cadmium exposure in the mouse leads to increased heart weight at birth and programs susceptibility to hypertension in adulthood.
Hudson KM, Belcher SM & Cowley M (2019) Sci Rep, 9:13553.

Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study.
Martin CL, Jima DD, Sharp GC, McCullough LE, Park SS, Gowdy KM, Skaar DA, Cowley M, Maguire RL, Fuemmeler B, Collier D, Relton CL, Murphy SK & Hoyo C (2019) Epigenetics, 14(4):325.

Neonatal mice exposed to a high fat diet in utero influence the behavior of their nursing dam.
Baptissart M, Lamb HE, To K, Bradish C, Tehrani J, Reif D & Cowley M (2018) Proc R Soc B, 285:20181237.

Comment in: John RM (2019) Prenatal adversity modulates the quality of maternal care via the exposed offspring. Bioessays, 41(6):e1900025.

Effects of cadmium exposure on DNA methylation at imprinting control regions and genome-wide in mothers and newborn children.
Cowley M*, Skaar DA, Jima DD, Maguire R, Hudson KM, Park SS, Sorrow P & Hoyo C (2018) Environ Health Perspect, 126(3):037003. *corresponding author

Developmental origins of health and disease.
Cowley (2018) In Smart RC, Hodgson E (Eds.), Molecular and Biochemical Toxicology Fifth Edition (pp.933-943). Hoboken, NJ: Wiley & Sons, Inc.

Regulatory links between imprinted genes: evolutionary predictions and consequences.
Patten MM, Cowley M, Oakey RJ & Feil R (2016) Proc R Soc B, 283(1824).

Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes.
Madon-Simon M, Cowley M, Garfield AS, Moorwood K, Bauer SR & Ward A (2014) BMC Biol, 12(1):771.

Comment in: Haig D (2014) Frugal fat or munificent muscle: genomic imprinting and metabolism. BMC Biol, 12(1):772.

Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup. Cowley M, Garfield AS, Madon-Simon M, Charalambous M, Clarkson RW, Smalley MJ, Kendrick H, Isles AR, Parry AJ, Carney S, Oakey RJ, Heisler K, Moorwood K, Wolf JB & Ward A (2014) PLoS Biol, 12(2):e1001799.

Comment in: Wilkins JF (2014) Genomic imprinting of Grb10: Coadaptation or conflict? PLoS Biol, 12(2):e1001800.

Comment in: Ubeda F & Gardner A (2015) Mother and offspring in conflict: why not? PLoS Biol, 13(3):e1002084.

Response to Ubeda & Gardner: Wolf JB, Cowley M & Ward A (2015) Coadaptation between mother and offspring: why not? PLoS Biol, 13(3):e1002085.

Transposable elements re-wire and fine-tune the transcriptome.
Cowley M & Oakey RJ (2013) PLoS Genet, 9(1): e1003234.

Resetting for the next generation.
Cowley M & Oakey RJ (2012) Mol Cell, 48(6):819-21.

Epigenetic control of alternative mRNA processing at the imprinted Herc3/Nap1l5 locus.
Cowley M, Wood AJ, Böhm S, Schulz R & Oakey RJ (2012) Nucleic Acids Res, 40(18):8917-26.

Protection against de novo methylation is instrumental in maintaining parent-of-origin methylation inherited from the gametes.
Proudhon C, Duffié R, Ajjan S, Cowley M, Carbajosa G, Iranzo J, Holland M, Oakey RJ, Rakyan V, Schulz R & Bourc’his D (2012) Mol Cell, 47(6):909-20.

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10.
Garfield AS, Cowley M, Smith FM, Moorwood K, Stewart-Cox JE, Gilroy K, Baker S, Xia J, Dalley JW, Hurst LD, Wilkinson LS, Isles AR & Ward A (2011) Nature, 469:534-8.

Comment in: Haig D & Ubeda F (2011) Genomic imprinting: an obsession with depilatory mice. Curr Biol, 21:R257-9.

Comment in: Curley JP (2011) Is there a genomically imprinted social brain? Bioessays, 33:662-8.

Short interspersed element (SINE) depletion and long interspersed element (LINE) abundance are not features universally required for imprinting.
Cowley M, de Burca A, McCole RB, Chahal M, Saadat G, Oakey RJ & Schulz R (2011) PLoS ONE, 6(4): e18953.

Human imprinted retrogenes have small DMRs that exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes.
Monk D, Arnaud P, Frost JM, Wood AJ, Cowley M, Trullijo AM, Adkins AG, Platas II, Camprubi C, Bourc’his D, Feil R, Moore GE & Oakey RJ (2011) Nucleic Acids Res, 39(11):4577-86.

Retrotransposition and genomic imprinting.
Cowley M & Oakey RJ (2010) Brief Funct Genomics, 9(4):340-6.

Maternally-inherited Grb10 reduces placental size and efficiency.
Charalambous M, Cowley M, Geoghegan F, Smith FM, Radford EJ, Marlow BP, Graham CF, Hurst LD & Ward A (2010) Dev Biol, 337(1):1-8.

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